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28 December 2011

Fischer Oxazole Synthesis

E. Fischer, Ber. 29, 205 (1896).

Condensation of equimolar amounts of aldehyde cyanohydrins and aromatic aldehydes in dry ether in the presence of dry hydrochloric acid:


R. H. Wiley, Chem. Rev. 37, 410 (1945); J. W. Cornforth, R. H. Cornforth, J. Chem. Soc. 1949, 1028; J. W. Cornforth, Heterocyclic Compounds 5, 309 (1957); T. Onaka, Tetrahedron Letters 1971, 4391.

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